Information Design and Usability
guuui.com: The interaction designer's coffee break
A List Apart: Exploring the process of developing web content
Boxes and Arrows: Improving information architecture and interactive design
Good Experience: Focuses on the customer experience
OK/Cancel: Usamajility? Sounds hard.
Signal vs. Noise: A design and usability blog
Use It: You know this one...Jakob Nielsen's website
Ed Foster's Gripelog: Where consumers vent their frustrations with technology

Voices
Doc Searls: Random thoughts and provocative questions from an A-list blogger
Hugh MacLeod: Barbed humor and new media insights
Tim Berners-Lee: Often dormant blog from the creater of the web
Bruce Tognazzini: Interaction design solutions for the real world
Don Norman: Site of the author of "The Design of Everyday Things"

Technology
Smart Mobs: Takes a close look at how mobile tech is changing our world
Unmediated: Tracking the tools that decentralize media
Tagsonomy: Examines the development of ad hoc organization
Gizmodo: The blog for all the folks with unhealthy gadget obsessions

Organizations
Electronic Frontier Foundation: Non-profit that seeks to protect digital rights
Society for Technical Communication: Professional organization for TC folks
Seattle Weblogs: Locals represent on the internet

Web Art
Grafik Dynamo: A dynamically generated web comic
Exploding Dog: Brilliant web art by Sam Brown
Slow Wave: Compact comics derived from dreams
Scott McCloud: Speculations about digital comics